Jorge Llibre-Guerra, MD

Dr. Llibre’s research focuses on the epidemiology and genetic pathways implicated in neurodegeneration, early markers of dementia, dementia prevention, and clinical trials in dementia.

Jorge Llibre completed his medical training at the Medical University of Havana, followed by residency in neurology at the National Institute of Neurology, where he was Chief Resident. He has received awards from the Ministry of Health, American Academy of Neurology, World Federation of Neurology, and Havana School of Medicine. University College London awarded him a training experience on Global Mental Health. Llibre created and oversaw the Cognitive and Behavior Research Unit at the National Institute of Neurology in order to help meet the needs of the aging population and was tapped to help in the National Strategy for Dementia and Alzheimer Disease. Llibre was funded by the World Federation of Neurology to develop a dementia-training program for health care providers in Cuba. He joined the Global Brain Health Institute at the Memory and Aging Center, UCSF, where received fellowship training in Behavioral Neurology and Global Mental Health. His research focuses on health disparities in dementia, biomarkers, and neuropsychology of Alzheimer’s disease. Recent work focuses on the influence of African Ancestry markers on cognitive decline in AD.

Selected publications:
Llibre-Guerra JJ, Li Y, Allegri RF, Mendez PC, Surace EI, Llibre-Rodriguez JJ, Sosa AL, Aláez-Verson C, Longoria EM, Tellez A, Carrillo-Sánchez K, Flores-Lagunes LL, Sánchez V, Takada LT, Nitrini R, Ferreira-Frota NA, Benevides-Lima J, Lopera F, Ramírez L, Jiménez-Velázquez I, Schenk C, Acosta D, Behrens MI, Doering M, Ziegemeier E, Morris JC, McDade E, Bateman RJ. Dominantly inherited Alzheimer’s disease in Latin America: Genetic heterogeneity and clinical phenotypes. Alzheimers Dement. 2021 Apr;17(4):653-664. PubMed Central PMCID: PMC8140610.

Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E. Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. JAMA Netw Open. 2019 Dec 2;2(12):e1917126. PubMed Central PMCID: PMC6991202.

McDade E, Llibre-Guerra JJ, Holtzman DM, Morris JC, Bateman RJ. The informed road map to prevention of 3 Alzheimer Disease: A call to arms. Molecular Neurodegeneration. 2021 July; 16.