Yen Ying Lim, PhD

Dr Yen Ying Lim is head of the Cognitive Health and Ageing Outcomes lab at the Florey Institute of Neuroscience and Mental Health in Melbourne, Australia. She is also the primary investigator of the Healthy Brain Project. Her primary research interests are in integrating and translating the effects of genetic, biological, and lifestyle factors on cognitive decline and clinical disease progression in Alzheimer’s disease. She has published 63 research papers and 2 book chapters. She has a sustained track record of winning fellowships including an NHMRC Career Development Fellowship, and an NHMRC/ARC Dementia Research Development Fellowship. She is also actively involved in the development and validation of computerised cognitive tests in the detection of amyloid-related cognitive change in preclinical Alzheimer’s disease, including the International Shopping List Test (ISLT) and the Online Repeated Cognitive Assessment (ORCA) battery.

Selected publications:
Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, et al. (2018). Effect of BDNF Val66Met on disease markers in dominantly inherited AD. Annals of Neurology, 84(3), 424-435.

Lim YY, Kalinowski P, Pietrzak RH, Laws SM, Villemagne VL, Porter T et al. (2018) Association of β-amyloid and apolipoprotein E ε4 with memory decline in preclinical Alzheimer’s disease. JAMA Neurology, 75(4), 488-494.

Lim YY & Mormino EM. (2017). APOE genotype and early beta-amyloid accumulation in non-demented older adults. Neurology, 89(10), 1028-1034.

Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TLS et al. (2016). BDNF Val66Met moderates cognitive impairment, neuronal dysfunction and tau in preclinical autosomal dominant Alzheimer’s disease. Brain, 139(Pt 10), 2766-2777.

Lim YY, Laws SM, Villemagne VL, Pietrzak RH, Porter T, Ames D et al. (2016). Aβ-related memory decline in APOE ε4 non-carriers: Implications for early Alzheimer’s disease. Neurology, 86(17), 1635-1642.